Research Scientist: Biochemistry & Biophysics

SyntheX is seeking a full-time on-site Research Scientist in Biochemistry & Biophysics in San Francisco, CA. The role involves conducting experiments, analyzing data, and collaborating with the research team to advance drug discovery. Candidates should have a Ph.D. in a related field and extensive lab experience, particularly in recombinant protein expression and purification, as well as biophysical techniques for analyzing protein interactions.
Company Description

SyntheX is a biotech company based in San Francisco, CA, focused on advancing precision drug discovery through synthetic biology. Our ToRFLEx platform utilizes genetically engineered circuits and intracellular drug selection to identify novel compounds targeting protein-protein interactions and developing molecular glues for targeted protein degradation. We power our internal oncology pipeline and collaborate externally to create safer and more durable therapeutics.

Role Description

This is a full-time on-site role for a Research Scientist specializing in Biochemistry & Biophysics at SyntheX. The Research Scientist will be responsible for conducting experiments, analyzing data, and collaborating with the research team to advance drug discovery efforts.

Requirements
• Ph.D., Biochemistry, Biophysics, Molecular Biology or closely related field with expertise in recombinant protein expression, purification and characterization from various expression systems (insect cell culture is a strong plus)
• 5+ years of lab experience in demanding, analytical work environment is preferred
• 2+ years of biotech start-up or industry experience is highly valued, but not a prerequisite

Skills and Experience
• Biochemistry skills with extensive experience in recombinant protein expression and purification, enzymology, and protein chemistry using various expression systems
• Hands on experience with chromatography systems such as GE ÄKTA and comfort with writing or adapting protocol scripts
• Experience using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions; using techniques such as Homogeneous Time-Resolved Fluorescence (HTRF), AlphaScreen, Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), Fluorescence Polarization/Anisotropy (FP), and Surface Plasmon Resonance (SPR) is preferred
• Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
• Experience completing in vitro high-throughput screens (HTS) of large small molecule libraries using HTRF or AlphaScreen, from design to execution, analysis, and validation
• Experience with structural biology (X-ray Crystallography or Cryo-EM or Nuclear Magnetic Resonance (NMR) for proteins) and modeling (using Alphafold or Rosetta) is appreciated but not required
• Adhering to good documentation and lab note keeping standards
• A passion for science!

Responsibilities
• As a key team member, the candidate will be involved in designing, optimizing, establishing and executing a wide-range of biochemical and biophysical assays to support our discovery programs
• Think critically and creatively to generate and execute ideas to positively impact project goals
• Independently select appropriate methods and techniques in performing experiments
• Recommend alternatives; research new methods and techniques and proactively seeks out potential solutions to problems
• Independently write technical reports and technical presentations within the area of expertise
• Provide regular project updates in team meetings
• Work independently and effectively on multiple programs in a dynamic environment
• Train and manage research assistants focused on protein purification and biophysical assays
• Demonstrate strong motivation, attention to detail, independent thinking, and the ability to fully integrate into a high achieving team environment
• Possess strong scientific and laboratory skills with a keen eye for detail and a passion for science, innovation and learning

Development Opportunities

This role offers a unique opportunity to be part of growing a company. It offers significant exposure to new scientific research and development. A successful candidate will have the opportunity for career progression and professional growth as the company grows. It is an opportunity to work with a small, dedicated, and diverse professional team working towards the goal of expanding the drug discovery toolkit and helping advance therapies to patients.