Postdoctoral Fellows: Single Cell Multiomics and Cancer Epigenome Regulation

The Cleveland Clinic's Lerner Research Institute is seeking a Postdoctoral Fellow for research in Single Cell Multiomics and Cancer Epigenome Regulation. The position involves studying brain tumor development and cancer immunity mechanisms in Frank Xie's lab. Candidates should have a Ph.D. or M.D., a strong publication record, and experience in molecular and computational biology. The role is based in Cleveland, OH, with competitive NIH-standard salaries and benefits.
A postdoctoral position is available in Frank Xie lab at the Cleveland Clinic Lerner Research Institute (LRI) and Case Comprehensive Cancer Center. The postdoctoral fellow is expected to study two funded directions: (1) Single-cell multi-omics of the spatiotemporal regulation of brain tumor development (NIH); and (2) Epigenomic mechanisms in cancer and immunity (NIH/DOD).

The Xie lab is located in the historic city of Cleveland, Ohio, where the 100-year-old Cleveland Clinic is ranked as one of the top two national hospital systems. Xie Lab develops unique tools and integrates super-resolution imaging, high-throughput sequencing, and genome engineering approaches to study fundamental regulatory mechanisms in development and disease (e.g., cancer). Representative research articles include: Xie et al., Nature Methods, 2020; Xie et al, Nature Genetics, 2022; King*, Yost*, Xie* et al., Nature, 2021; Xie et al., Mol.Sys.Bio, 2021; Xie et al., Genes & Development, 2017; Knight, Xie et al., Science, 2015. More details can be found at https://frankxielab.com/.

The Xie lab currently has 5 postdoctoral fellows, 1 Ph.D. Student, and 2 research technicians. We are building a multidisciplinary team of biologists, physicians, data scientists, tool builders, engineers, and others to study the frontiers of genome regulation in development, cancer, and immunity. We hope to apply our basic findings to translational medicine. We are recruiting one more enthusiastic and motivated postdoctoral researcher to study emerging questions about single cell biology and cancer genome regulation. Candidates should have a Ph.D. and/or M.D. degree with a proven track record of research publications (e.g., peer-reviewed first author articles) and excellent English communication skills. In this recruitment cycle, preference will be given to self-driven and detail-oriented candidates with prior solid experience in molecular biology and computational biology.

Postdoctoral salaries are based on NIH standards and commensurate with past research experience. Excellent Cleveland Clinic’s insurance and benefit packages are included. Successful candidates will have access to Cleveland Clinic’s vast computational (e.g., IBM Quantum Computing), clinical, and medical resources and collaborate with physician scientists and clinicians to translate benchside research to bedside. Postdoctoral fellows will conduct mentored independent research, lead cutting-edge projects, gain solid research experience, and participate in guided collaborations, with the encouragement to develop unconventional ideas, risky projects, and cross-disciplinary frontiers. By the end of the training, postdoctoral candidates are anticipated to be equipped with top-tier journal publications, critical thinking, multidisciplinary mindsets, and excellent communication skills competitive for their next level of career advancement.

Interested individuals should directly email Dr. Liangqi (Frank) Xie at XIEL2@ccf.org and xielab.2021@gmail.com with the title line as Xie_lab_Postdoc_Application

The postdoctoral fellow application material must include the following information.

1) A cover letter describing prior research background, future research interests, career goals, and estimated start time.

2) A CV, including publications and contact information for 3 referees.